Supra-oesophageal manifestations of gastro-oesophageal reflux disease

Eur J Gastroenterol Hepatol. 2003 Dec;15(12):1339-50. doi: 10.1097/00042737-200312000-00013.


Since the early 1960s, many studies have been published that consider the possible relationship between gastro-oesophageal (acid) reflux (GORD) and various other complaints, including dental erosions, ear, nose and throat problems, chronic cough and asthma. Although a high coincidence of GORD and these supra-oesophageal complaints have been noted, there is no consensus on the pathophysiology and management of such complications. In this article we review the literature published between 1966 and 2000 on this subject. We also analyse the available information on the incidence, pathophysiological mechanisms, diagnostic approach and therapeutic options in the various subgroups of disorders.

Publication types

  • Review

MeSH terms

  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / physiopathology
  • Gastroesophageal Reflux / therapy
  • Humans
  • Mouth Diseases / etiology
  • Otorhinolaryngologic Diseases / etiology
  • Respiratory Tract Diseases / etiology