Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study

J Infect Dis. 2003 Nov 15;188(10):1508-16. doi: 10.1086/379197. Epub 2003 Nov 3.


The association between dietary intake and persistence of type-specific human papillomavirus (HPV) infection, during a 12-month period, among 433 women participating in the Ludwig-McGill HPV Natural History Study was evaluated by use of a nested case-control design. Dietary intake was assessed by a food-frequency questionnaire at the month-4 visit. HPV status was assessed at months 0, 4, 8, and 12 by polymerase chain reaction (MY09/11). Only women who ever tested positive for HPV were included in the present study: 248 had transient HPV infections (1 of 4 positive tests or nonconsecutively positive), and 185 had persistent HPV infections (> or =2 consecutive tests positive for the same HPV type). Risk of type-specific, persistent HPV infection was lower among women reporting intake values of beta-cryptoxanthin and lutein/zeaxanthin in the upper 2 quartiles and intake values of vitamin C in the upper quartile, compared with those reporting intake in the lowest quartile. Consumption of papaya > or =1 time/week was inversely associated with persistent HPV infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Ascorbic Acid / metabolism
  • Brazil
  • Case-Control Studies
  • Cohort Studies
  • Cryptoxanthins
  • Feeding Behavior
  • Female
  • Fruit / metabolism
  • Humans
  • Longitudinal Studies
  • Lutein / blood
  • Nutritional Status / physiology*
  • Papillomaviridae / growth & development*
  • Papillomavirus Infections / etiology*
  • Poverty
  • Surveys and Questionnaires
  • Tumor Virus Infections / etiology*
  • Urban Population
  • Xanthophylls
  • beta Carotene / analogs & derivatives*
  • beta Carotene / blood


  • Cryptoxanthins
  • Xanthophylls
  • beta Carotene
  • Ascorbic Acid
  • Lutein