Bench-to-bedside review: microvascular and airspace linkage in ventilator-induced lung injury

Crit Care. 2003 Dec;7(6):435-44. doi: 10.1186/cc2392. Epub 2003 Oct 17.


Experimental and clinical evidence point strongly toward the potential for microvascular stresses to influence the severity and expression of ventilator associated lung injury. Intense microvascular stresses not only influence edema but predispose to structural failure of the gas-blood barrier, possibly with adverse consequences for the lung and for extrapulmonary organs. Taking measures to lower vascular stress may offer a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS.

Publication types

  • Review

MeSH terms

  • Animals
  • Capillary Permeability / physiology
  • Humans
  • Positive-Pressure Respiration
  • Respiration, Artificial / adverse effects*
  • Respiratory Distress Syndrome / classification
  • Respiratory Distress Syndrome / etiology
  • Respiratory Distress Syndrome / physiopathology*
  • Severity of Illness Index