The morphogen sonic hedgehog collaborates with netrin-1 to guide axons in the spinal cord

Trends Neurosci. 2003 Dec;26(12):641-3. doi: 10.1016/j.tins.2003.09.006.


Netrin-1 is an attractive axon guidance molecule required for the proper navigation of commissural axons to the floor plate in the spinal cord. A new study now shows that sonic hedgehog (Shh) from midline structures collaborates with netrin-1 to guide commissural axons. This new role for the morphogen Shh raises the possibility that principles similar to those used to establish positional information in embryonic patterning are also employed during axon navigation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Hedgehog Proteins
  • Humans
  • Nerve Growth Factors / physiology*
  • Netrin-1
  • Neural Pathways / growth & development
  • Neural Pathways / physiology
  • Spinal Cord / growth & development
  • Spinal Cord / physiology*
  • Trans-Activators / physiology*
  • Tumor Suppressor Proteins


  • Hedgehog Proteins
  • NTN1 protein, human
  • Nerve Growth Factors
  • SHH protein, human
  • Trans-Activators
  • Tumor Suppressor Proteins
  • Netrin-1