Is it time to move to multidrug combinations?

Am J Hypertens. 2003 Nov;16(11 Pt 2):36S-40S. doi: 10.1016/j.amjhyper.2003.07.005.


The clinical benefit of aggressive blood pressure (BP) control in reducing adverse cardiovascular and renal outcomes is well documented. However, a majority of patients with hypertension remain poorly controlled with monotherapy and require two or more agents to achieve their target BP levels. Patients with hypertension who also have diabetes or renal disease benefit from even lower BP targets, but may be more difficult to treat and require three or more drugs to achieve control. Using two or more drugs, each at lower doses, is usually more effective and less commonly associated with adverse effects than higher doses of a single drug. With the increasing prevalence of diabetes and renal disease, the treatment of hypertensive patients with multidrug combinations will become even more common. Knowing how specific combinations can be used effectively will be an important component of the treatment strategy for hypertension.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / administration & dosage
  • Antihypertensive Agents / therapeutic use*
  • Diabetes Complications
  • Diabetes Mellitus / drug therapy
  • Drug Therapy, Combination
  • Humans
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Meta-Analysis as Topic
  • Randomized Controlled Trials as Topic
  • Renal Insufficiency / complications
  • Renal Insufficiency / drug therapy


  • Antihypertensive Agents