[Effect of astragalus injection combined with chemotherapy on quality of life in patients with advanced non-small cell lung cancer]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Oct;23(10):733-5.
[Article in Chinese]


Objective: To observe the effect of Astragalus injection (AI) combined with chemotherapy on quality of life (QOF) in patients with advanced non-small cell lung caner (NSCLC).

Methods: Sixty-NSCLC patients were randomly divided into the treated group (n = 30, treated with AI combined with chemotherapy) and the control group (n = 30, treated with chemotherapy alone). Chemotherapy of MVP protocol was applied to both groups. AI was supplemented to the treated group by intravenous dripping 60 ml per day. Treatment of 21-28 days as one treatment cycle, and 2-3 treatment cycles were applied.

Results: The effective rate in the treated group was 40.0% and in the control group was 36.7%, the mean remission rate in the treated and control group was 5.4 months and 3.3 months, the median survival period 11 months and 7 months, and the 1-year survival rate 46.75% and 30.0%, respectively, the differences of these indexes between the two groups were all significant (P < 0.05). Moreover, the clinical improving rate and QOF elevation rate in the treated group was 80.4% and 43.3%, as compared with those in the control group (50.0% and 23.3% respectively), the difference was also significant (P < 0.01).

Conclusion: AI combined with chemotherapy can significantly improve the QOF in NSCLC patients of advanced stage.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Astragalus propinquus*
  • Carcinoma, Non-Small-Cell Lung / drug therapy*
  • Carcinoma, Squamous Cell / drug therapy
  • Cisplatin / therapeutic use
  • Drug Therapy, Combination
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Humans
  • Lung Neoplasms / drug therapy*
  • Male
  • Middle Aged
  • Mitomycins / therapeutic use
  • Phytotherapy*
  • Quality of Life
  • Vinblastine / therapeutic use


  • Drugs, Chinese Herbal
  • Mitomycins
  • Vinblastine
  • Cisplatin

Supplementary concepts

  • MVP protocol 2