Projection pattern of nerve fibers from the septal organ: DiI-tracing studies with transgenic OMP mice

Histochem Cell Biol. 2003 Dec;120(6):483-92. doi: 10.1007/s00418-003-0594-4. Epub 2003 Nov 20.


The septal organ represents one of the three chemosensory subsystems found in most vertebrate species. Analyzing the projection pattern of septal organ neurons using the OMP-GFP transgenic mouse line revealed that axons navigate in highly variable fiber tracks across the main olfactory epithelium toward the main olfactory bulb. All septal organ axons cross through the cribriform plate at a spatially defined site and terminate exclusively in the posterior, ventromedial aspect of the bulb. Here, one portion of axons forms a dense network on the medial side where they apparently enter glomeruli which are mainly innervated by axons of olfactory sensory neurons from the main olfactory epithelium. Another significant portion of the axons targets a few glomeruli which appear to receive input exclusively from the septal organ neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons*
  • Carbocyanines
  • Green Fluorescent Proteins
  • Luminescent Proteins
  • Mice
  • Mice, Transgenic
  • Microscopy, Confocal
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Olfactory Marker Protein
  • Olfactory Mucosa / cytology
  • Olfactory Mucosa / innervation*


  • Carbocyanines
  • Luminescent Proteins
  • Nerve Tissue Proteins
  • Olfactory Marker Protein
  • Omp protein, mouse
  • Green Fluorescent Proteins
  • 3,3'-dioctadecylindocarbocyanine