Role of regulatory T cells in allergy and asthma

Curr Opin Immunol. 2003 Dec;15(6):627-33. doi: 10.1016/j.coi.2003.09.012.


Th2 cells play a critical role in the pathogenesis of allergy and asthma. However, the immunological mechanisms that downmodulate and protect against the development of these disorders are poorly understood. A spectrum of CD4(+) T cells, including Th3 cells, T(R) cells, CD4(+)CD25(+) cells and NKT cells play a critical role in regulating these diseases. A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets.

Publication types

  • Review

MeSH terms

  • Animals
  • Asthma / immunology*
  • CD4 Antigens / immunology
  • Humans
  • Hypersensitivity / immunology*
  • Immune Tolerance / immunology
  • Receptors, Interleukin-2 / immunology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology*


  • CD4 Antigens
  • Receptors, Interleukin-2