Molecular organization of axo-glial junctions

Curr Opin Neurobiol. 2003 Oct;13(5):552-9. doi: 10.1016/j.conb.2003.09.004.


Axo-glial interactions are required for the organization of highly specialized molecular domains in myelinated axons. The molecular composition of these domains includes cell adhesion molecules, ion channels and cytoskeletal proteins. Recent genetic and molecular studies provide new insights into how these macromolecular complexes are assembled and organized into functional domains, and how the loss of individual components affects domain organization and function. More importantly, the key molecular components identified at the vertebrate axo-glial septate junctions are also present at the Drosophila septate junctions. In addition, new roles for axo-glial paranodal septate junctions have emerged, which suggest that the paranodal region may act as an ionic barrier and a molecular fence in myelinated axons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Axons / metabolism*
  • Humans
  • Myelin Sheath / chemistry
  • Myelin Sheath / metabolism*
  • Neuroglia / metabolism*
  • Ranvier's Nodes / metabolism*