Systems biology in neuroscience: bridging genes to cognition

Curr Opin Neurobiol. 2003 Oct;13(5):577-82. doi: 10.1016/j.conb.2003.09.016.


Systems biology is a new branch of biology aimed at understanding biological complexity. Genomic and proteomic methods integrated with cellular and organismal analyses allow modelling of physiological processes. Progress in understanding synapse composition and new experimental and bioinformatics methods indicate the synapse is an excellent starting point for global systems biology of the brain. A neuroscience systems biology programme, organized as a consortium, is proposed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cognition / physiology*
  • Humans
  • Molecular Biology / methods
  • Neural Networks, Computer*
  • Neurosciences / methods*
  • Systems Theory*