Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid: a useful marker for the diagnosis of normal pressure hydrocephalus

Neurosci Res. 2003 Dec;47(4):455-9. doi: 10.1016/j.neures.2003.08.009.


Lipocalin-type prostaglandin D synthase (PGDS) is considered to be mainly produced in the leptomeninges and secreted into cerebrospinal fluid (CSF). We found PGDS levels in CSF of patients with normal pressure hydrocephalus (NPH) (8.99+/-2.59 microg/ml, mean+/-S.D., n=14) to be significantly lower than levels in a control (15.29+/-5.17, n=14, P<0.0001) and other dementia group (19.14+/-4.34, n=7, P=0.0003). Thus, PGDS level in CSF is a useful marker for the differential diagnosis of NPH from other diseases with dementia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers / cerebrospinal fluid
  • Dementia / cerebrospinal fluid
  • Diagnosis, Differential
  • Female
  • Humans
  • Hydrocephalus, Normal Pressure / cerebrospinal fluid*
  • Intramolecular Oxidoreductases / cerebrospinal fluid*
  • Lipocalins
  • Male
  • Middle Aged


  • Biomarkers
  • Lipocalins
  • Intramolecular Oxidoreductases
  • prostaglandin R2 D-isomerase