A comparison of two popular statistical methods for estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences

J Genet. Apr-Aug 2003;82(1-2):7-12. doi: 10.1007/BF02715874.

Abstract

We have compared two statistical methods of estimating the time to most recent common ancestor (TMRCA) from a sample of DNA sequences, which have been proposed by Templeton (1993) and Bandelt et al. (1995). Monte-Carlo simulations were used for generating DNA sequence data. Different evolutionary scenarios were simulated and the estimation procedures were evaluated. We have found that for both methods (i) the estimates are insensitive to demographic parameters and (ii) the standard deviations of the estimates are too high for these methods to be reliably used in practice.

Publication types

  • Comparative Study

MeSH terms

  • Algorithms
  • Animals
  • Computer Simulation
  • DNA / genetics*
  • Demography
  • Evolution, Molecular*
  • Humans
  • Models, Genetic
  • Monte Carlo Method
  • Statistics as Topic*
  • Time Factors

Substances

  • DNA