Purulent pericarditis induced by endobronchial needle injection of adenoviral-mediated gene therapy

Can J Cardiol. 2003 Nov;19(12):1421-3.

Abstract

A case of a 65-year-old man who presented with cardiac tamponade and was diagnosed with Staphylococcus aureus purulent pericarditis is reported. The patient had recently undergone bronchoscopic endobronchial needle injection of gene therapy for recurrent lung cancer. It was felt that incidental, direct inoculation of contaminated contents into the pericardium, versus mediastinal seeding with direct extension, had occurred. Following pericardiocentesis and antibiotic therapy, the patient fully recovered. The present case is the first reported incidence of purulent pericarditis induced by bronchoscopic injection of gene therapy.

Publication types

  • Case Reports

MeSH terms

  • Adenoviridae / genetics*
  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Carcinoma, Non-Small-Cell Lung / therapy
  • Cardiac Tamponade / diagnostic imaging
  • Cardiac Tamponade / therapy
  • Echocardiography, Doppler
  • Genes, p53
  • Genetic Therapy / adverse effects*
  • Genetic Therapy / methods
  • Humans
  • Injections / adverse effects*
  • Lung Neoplasms / therapy
  • Male
  • Pericardiocentesis
  • Pericarditis / diagnostic imaging
  • Pericarditis / drug therapy
  • Pericarditis / microbiology*
  • Pericardium / diagnostic imaging
  • Pericardium / microbiology
  • Staphylococcal Infections / diagnostic imaging
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / isolation & purification
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents