Elastase involvement in extracellular and intracellular collagen degradation during postpartum involution of the uterus

Bull Exp Biol Med. 2003 Aug;136(2):206-8. doi: 10.1023/a:1026395613444.

Abstract

The location of elastase in rat uterus during its postpartum involution was studied by electron histochemical method. Intense extracellular activity of the enzyme was detected: the reaction product was found on the cytolemma of smooth-muscle cells and, to a lesser extent, on the cytolemma of macrophages and fibroblasts and on adjacent collagen fibrils. The reaction product was also found in vacuoles with collagen in macrophages and fibroblasts.

MeSH terms

  • Animals
  • Collagen / metabolism*
  • Female
  • Fibroblasts / metabolism
  • Fibroblasts / ultrastructure
  • Macrophages / metabolism
  • Macrophages / ultrastructure
  • Pancreatic Elastase / metabolism*
  • Postpartum Period*
  • Pregnancy
  • Rats
  • Uterus / enzymology*
  • Uterus / physiology
  • Uterus / ultrastructure

Substances

  • Collagen
  • Pancreatic Elastase