The role of cell cycle proteins in Glomerular disease

Semin Nephrol. 2003 Nov;23(6):569-82. doi: 10.1053/s0270-9295(03)00133-5.


Although initially identified and characterized as regulators of the cell cycle and hence proliferation, an extended role for cell cycle proteins has been appreciated more recently in a number of physiologic and pathologic processes, including development, differentiation, hypertrophy, and apoptosis. Their precise contribution to the cellular response to injury appears to be dependent on both the cell type and the nature of the initiating injury. The glomerulus offers a remarkable situation in which to study the cell cycle proteins, as each of the 3 major resident cell types (the mesangial cell, podocyte, and glomerular endothelial cell) has a specific pattern of cell cycle protein expression when quiescent and responds uniquely after injury. Defining their roles may lead to potential therapeutic strategies in glomerular disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Cell Cycle Proteins / metabolism*
  • Cell Cycle Proteins / physiology
  • Cell Division
  • Cells, Cultured
  • Cyclin-Dependent Kinases / metabolism
  • Glomerular Mesangium / cytology
  • Glomerular Mesangium / metabolism
  • Glomerulonephritis / etiology*
  • Glomerulonephritis / physiopathology*
  • Humans
  • Kidney Glomerulus / metabolism*
  • Kidney Glomerulus / physiology
  • Prognosis
  • Sensitivity and Specificity


  • Cell Cycle Proteins
  • Cyclin-Dependent Kinases