Supplementing with beta-hydroxy-beta-methylbutyrate (HMB) to build and maintain muscle mass: a review

Res Commun Mol Pathol Pharmacol. 2002;111(1-4):139-51.


Beta-hydroxy-beta-methylbutyrate, more commonly referred to as HMB, is derived from the amino acid, leucine, and its keto acid, alpha-ketoisocaproate. In several studies combining HMB supplementation and resistance exercise, researchers have concluded that HMB may play an important role in reducing protein degradation and/or increasing recovery of damaged muscle cells. These actions could be advantageous to all individuals participating in exercise programs and improve the lives of many by overcoming weakness or frailty.

Publication types

  • Review

MeSH terms

  • Exercise
  • Humans
  • Hydrolysis
  • Muscle Proteins / metabolism
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / growth & development
  • Muscle, Skeletal / metabolism
  • Valerates / administration & dosage*


  • Muscle Proteins
  • Valerates
  • beta-hydroxyisovaleric acid