Simian virus 40 sequences in malignant lymphomas in Japan

Cancer Res. 2003 Nov 15;63(22):7606-8.


Recent studies showed that SV40 is detected in >40% of non-Hodgkin's lymphoma (NHL) in United States, suggesting SV40-contaminated poliovaccines widely used during the period 1955-1963 to be a major source of SV40 in NHL. We examined the presence of SV40 sequences in 122 cases with NHL and 3 with Hodgkin's lymphoma from Japan. The detection rate of SV40 sequences in diffuse large B-cell lymphoma (19%) was higher than that in peripheral blood cells of normal healthy volunteers in Japan (4.7%; P < 0.05) reported previously as controls for comparison with the study results from cancer patients, suggesting a role for SV40 in the development of diffuse large B-cell lymphoma. In contrast, the frequency of SV40 sequences in NHL cases born between 1951 and 1963 (12%), during which SV40-contaminated poliovaccines might have been inoculated, is not significantly different from that in cases born before 1950 (11%) or after 1964 (15%). SV40 is a new candidate etiologic factor for malignant lymphoma not only in the United States but also in Japan.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Polyomavirus Transforming / genetics
  • Child
  • Child, Preschool
  • Female
  • Humans
  • In Situ Hybridization
  • Infant
  • Japan
  • Lymphoma, B-Cell / genetics
  • Lymphoma, B-Cell / virology
  • Lymphoma, Large B-Cell, Diffuse / genetics
  • Lymphoma, Large B-Cell, Diffuse / virology
  • Lymphoma, Non-Hodgkin / genetics
  • Lymphoma, Non-Hodgkin / virology*
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / virology
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Simian virus 40 / genetics*


  • Antigens, Polyomavirus Transforming