Screening for gestational diabetes mellitus by a model based on risk indicators: a prospective study

Am J Obstet Gynecol. 2003 Nov;189(5):1383-8. doi: 10.1067/s0002-9378(03)00601-x.


Objective: This study was performed to prospectively evaluate a screening model for gestational diabetes mellitus on the basis of clinical risk indicators.

Study design: In a prospective multicenter study with 5235 consecutive pregnant women, diagnostic testing with a 2-hour 75-g oral glucose tolerance test was routinely performed in women with risk indicators and offered to women without risk indicators as part of the study.

Results: Forty-four percent of the women underwent testing, 43% declined participation, 6% did not speak Danish, and 7% could not be contacted. By extrapolation of the results from tested women to the whole group in question, a 2.4% prevalence of gestational diabetes mellitus was calculated. Sensitivity and specificity of the model was 80.6 (73.7-87.6) and 64.8 (63.5-66.1), respectively (95% CIs).

Conclusion: Under ideal conditions, sensitivity of the model was comparable with universal screening by fasting glucose or a 1-hour 50-g glucose challenge test. Both screening and diagnostic testing could be avoided in two thirds of all pregnant women.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adult
  • Diabetes, Gestational / diagnosis*
  • Diabetes, Gestational / epidemiology
  • Female
  • Glucose Tolerance Test
  • Humans
  • Mass Screening*
  • Models, Theoretical*
  • Predictive Value of Tests
  • Pregnancy
  • Prevalence
  • Prospective Studies
  • Risk Assessment
  • Risk Factors
  • Sensitivity and Specificity