A decade of caspases

Oncogene. 2003 Nov 24;22(53):8543-67. doi: 10.1038/sj.onc.1207107.


Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and pathological processes.

Publication types

  • Review

MeSH terms

  • Allosteric Regulation
  • Animals
  • Apoptosis*
  • Caspases / chemistry
  • Caspases / classification
  • Caspases / physiology*
  • Enzyme Activation
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Transcriptional Activation


  • Enzyme Inhibitors
  • Caspases