Clues to catastrophic telomere loss in mammals from yeast telomere rapid deletion

Nat Rev Genet. 2003 Nov;4(11):916-23. doi: 10.1038/nrg1207.


Catastrophic losses of telomeric sequences have recently been described during apoptosis, senescence and tumorigenesis in murine and human cells, in ataxia telangiectasia patients and in immortalized cells in which telomerase is inactive. A mechanism that underlies a single-step non-reciprocal telomere deletion called telomere rapid deletion in Saccharomyces cerevisiae might provide clues for future studies of catastrophic telomere loss in higher eukaryotes.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Mammals / genetics*
  • Neoplasms / genetics
  • Sequence Deletion*
  • Telomere*
  • Yeasts / genetics*