Comparison of several formulas to assess insulin action in the fasting state with the hyperglycemic-hyperinsulinemic clamp technique in healthy individuals

Rev Invest Clin. Jul-Aug 2003;55(4):419-22.

Abstract

Background: The aim of this study was to correlate several formulas to assess insulin action in the fasting state with the hyperglycemic-hyperinsulinemic clamp method in healthy individuals.

Methods: A cross-sectional study was carried out in 33 healthy, non-obese volunteers. A hyperglycemic-hyperinsulinemic clamp technique was performed and the following formulas to assess insulin action in the fasting state were calculated: reciprocal insulin, glucose to insulin ratio, homeostasis model analysis, Raynaud index, Belfiore index, reciprocal of fasting insulin resistance index and quantitative insulin sensitivity check index. Pearson correlation was used to correlate the above mentioned formulas with the clamp method.

Results: There were significant correlations between results of the several formulas and those obtained with the clamp technique. The reciprocal of insulin index had better correlation with the clamp method.

Conclusions: All formulas evaluated to assess insulin action in the fasting state had a significant correlation with the hyperglycemic clamp technique.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Cross-Sectional Studies
  • Fasting / blood*
  • Female
  • Glucose Clamp Technique / methods*
  • Humans
  • Hyperglycemia
  • Hyperinsulinism
  • Insulin / pharmacology*
  • Male

Substances

  • Insulin