NF-kappaB in mammary gland development and breast cancer

J Mammary Gland Biol Neoplasia. 2003 Apr;8(2):215-23. doi: 10.1023/a:1025905008934.

Abstract

Nuclear factor of kappaB (NF-kappaB) is a group of sequence-specific transcription factors that is best known as a key regulator of the inflammatory and innate immune responses. Recent studies of genetically engineered mice have clearly indicated that NF-kappaB is also required for proper organogenesis of several epithelial tissues, including the mammary gland. Mice have shown severe lactation deficiency when NF-kappaB activation is specifically blocked in the mammary gland. In addition, there are strong suggestions that NF-kappaB may play an important role in the etiology of breast cancer. Elevated NF-kappaB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / metabolism*
  • Cell Line, Tumor
  • Cyclin D1 / biosynthesis
  • Female
  • Humans
  • I-kappa B Kinase
  • Mammary Glands, Animal / metabolism*
  • Mammary Glands, Human / metabolism*
  • Mammary Neoplasms, Animal / metabolism*
  • Mice
  • Models, Biological
  • NF-kappa B / metabolism
  • NF-kappa B / physiology*
  • Phosphorylation
  • Pregnancy
  • Protein-Serine-Threonine Kinases / biosynthesis
  • Signal Transduction

Substances

  • NF-kappa B
  • Cyclin D1
  • Protein-Serine-Threonine Kinases
  • CHUK protein, human
  • Chuk protein, mouse
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human
  • Ikbkb protein, mouse
  • Ikbke protein, mouse