Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

Immunol Today. 1992 Dec;13(12):507-12. doi: 10.1016/0167-5699(92)90027-5.


This new view of the immunoreactivity of the normal brain is based on three key components. First, there is an active and highly-regulated communication between the brain and the central immune organs. Secondly, the connection from the brain to the draining nodes is much larger than previously appreciated. And third, the blood-brain barrier, by virtue of its selective permeability properties, contributes to the regulation of immunoregulatory cells and molecules in the brain cell microenvironment.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Albumins / metabolism
  • Animals
  • Antibody Formation
  • Antigens / administration & dosage
  • B-Lymphocytes / immunology
  • Blood-Brain Barrier / immunology*
  • Brain / immunology*
  • Cell Movement
  • Cerebrospinal Fluid / physiology
  • Extracellular Space / physiology
  • Injections, Intraventricular
  • Lymph / physiology*
  • Rats


  • Albumins
  • Antigens