MoMLV reverse transcriptase regulates its own expression

Cell. 2003 Oct 31;115(3):250-1. doi: 10.1016/s0092-8674(03)00850-x.

Abstract

A precise ratio of Gag:Gag-Pol expression is required for assembly of infectious retroviral virions. In this issue of Cell, Orlova et al. show that MoMLV reverse transcriptase binds the translation release factor eRF1, and that this interaction promotes translation readthrough to make Gag-Pol.

Publication types

  • Comment

MeSH terms

  • Animals
  • Fusion Proteins, gag-pol / biosynthesis*
  • Fusion Proteins, gag-pol / genetics
  • Mice
  • Moloney murine leukemia virus / enzymology*
  • Moloney murine leukemia virus / genetics
  • Moloney murine leukemia virus / physiology
  • Peptide Termination Factors / metabolism*
  • Protein Binding
  • Protein Biosynthesis*
  • RNA-Directed DNA Polymerase / genetics
  • RNA-Directed DNA Polymerase / metabolism*
  • Substrate Specificity
  • Virion / chemistry
  • Virion / metabolism
  • Virus Replication*

Substances

  • Etf1 protein, mouse
  • Fusion Proteins, gag-pol
  • Peptide Termination Factors
  • RNA-Directed DNA Polymerase