Global BOLD MRI changes to ventilatory challenges in congenital central hypoventilation syndrome

Respir Physiol Neurobiol. 2003 Dec 16;139(1):41-50. doi: 10.1016/j.resp.2003.09.006.


We evaluated global blood oxygen level dependent (BOLD) signal changes in gray and white matter in 14 congenital central hypoventilation syndrome (CCHS) and 14 control subjects. One baseline image series with room air and three series with 30 s room air followed by 120 s hypercapnia (5% CO2/95% O2), hypoxia (15% O2/85% N2) or hyperoxia (100% O2) were collected. Hypercapnia and hyperoxia raised, and hypoxia lowered gray and white matter global signal in both groups, with smaller changes in white matter. Signal changes in CCHS cases were lower than control subjects for hypercapnia in gray and white matter, slightly more-enhanced in hypoxia, and, except for initial transient responses, were nearly comparable during hyperoxia. Initial signal rate or pattern changes emerged in all three challenges in gray or white matter in control, but not CCHS cases. Neural or vascular mechanisms mediate perfusion differently in CCHS; the aberrant initial transient responses may reflect deficiencies in rapidly-varying physiologic interactions in the syndrome.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Blood Flow Velocity / physiology
  • Brain / blood supply*
  • Brain Mapping
  • Carbon Dioxide
  • Case-Control Studies
  • Child
  • Female
  • Humans
  • Hypercapnia
  • Hyperoxia
  • Hypoventilation / congenital
  • Hypoventilation / physiopathology*
  • Hypoxia
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging*
  • Male
  • Oxygen
  • Regional Blood Flow / physiology
  • Ventilators, Mechanical


  • Carbon Dioxide
  • Oxygen