Mobile elements and mammalian genome evolution

Curr Opin Genet Dev. 2003 Dec;13(6):651-8. doi: 10.1016/j.gde.2003.10.013.


Mobile elements make up large portions of most eukaryotic genomes. They create genetic instability, not only through insertional mutation but also by contributing recombination substrates, both during and long after their insertion. The combination of whole-genome sequences and the development of innovative new assays to test the function of mobile elements have increased our understanding of how these elements mobilize and how their insertion impacts genome diversity and human disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells
  • Evolution, Molecular*
  • Genetic Variation
  • Genome*
  • Genomic Instability
  • Humans
  • Interspersed Repetitive Sequences*
  • Mammals / genetics*
  • Retroelements / genetics*
  • Sequence Analysis, DNA


  • Retroelements