Subthalamic somatosensory evoked potentials in Parkinson's disease

Mov Disord. 2003 Nov;18(11):1341-5. doi: 10.1002/mds.10519.


Deep brain stimulation (DBS) of subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. It also provides an opportunity to record neural activity from the human basal ganglia. In this study, to investigate the involvement of the human STN in sensory functions, we recorded somatosensory evoked potentials (SEPs) elicited by contralateral median-nerve stimulation, from STN electrodes implanted for DBS in patients with Parkinson's disease. We suggest that the STN N18 component of SEPs in Parkinson's disease is a mainly local field potential elicited by muscle afferent input to the nucleus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Electric Stimulation / instrumentation
  • Electrodes, Implanted
  • Evoked Potentials, Somatosensory / physiology*
  • Female
  • Humans
  • Male
  • Median Nerve / physiology
  • Middle Aged
  • Muscle, Skeletal / innervation
  • Parkinson Disease / physiopathology*
  • Subthalamic Nucleus / physiopathology*