Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy

Mov Disord. 2003 Nov;18(11):1385-6. doi: 10.1002/mds.10540.

Abstract

In a case-control study using a clinically well-defined group of 30 multiple system atrophy (MSA) patients and 110 control subjects, homozygosity for interleukin-1A (IL-1A) allele 2 (high secretor of proinflammatory cytokine) in the regulatory region (-889) of the IL-1A gene was associated with a fivefold increased risk for MSA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Female
  • Genotype
  • Humans
  • Interleukin-1 / genetics*
  • Male
  • Middle Aged
  • Multiple System Atrophy / genetics*
  • Multiple System Atrophy / immunology*
  • Polymorphism, Genetic / genetics*
  • Promoter Regions, Genetic / genetics
  • Risk Factors

Substances

  • Interleukin-1