Buckwheat concentrate reduces serum glucose in streptozotocin-diabetic rats

J Agric Food Chem. 2003 Dec 3;51(25):7287-91. doi: 10.1021/jf0302153.


The antihyperglycemic effects of chemically synthesized d-chiro-inositol (d-CI), a component of an insulin mediator, have been demonstrated in rats. Buckwheat contains relatively high levels of d-CI: thus, it has been proposed as a source of d-CI for reducing serum glucose concentrations in diabetics. The present study evaluates the effects of a buckwheat concentrate, containing d-CI, on hyperglycemia and glucose tolerance in streptozotocin (STZ) rats. In fed STZ rats, both doses of the buckwheat concentrate (containing 10 and 20 mg of d-CI/kg of body weight) were effective for lowering serum glucose concentrations by 12-19% at 90 and 120 min after administration. Findings from this study demonstrate that a buckwheat concentrate is an effective source of d-CI for lowering serum glucose concentrations in rats and therefore may be useful in the treatment of diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / analysis*
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Fagopyrum / chemistry*
  • Fasting
  • Glucose Tolerance Test
  • Hypoglycemic Agents / administration & dosage*
  • Inositol Phosphates / administration & dosage
  • Inositol Phosphates / analysis
  • Kinetics
  • Male
  • Plant Extracts / administration & dosage*
  • Polysaccharides / administration & dosage
  • Polysaccharides / analysis
  • Rats
  • Rats, Sprague-Dawley
  • Seeds / chemistry*


  • Blood Glucose
  • Hypoglycemic Agents
  • Inositol Phosphates
  • Plant Extracts
  • Polysaccharides
  • inositol phosphate glycan