Rotting by radicals--the role of cellobiose oxidoreductase?

Biochem Soc Trans. 2003 Dec;31(Pt 6):1335-6. doi: 10.1042/bst0311335.


Cellobiose oxidoreductase is a flavocytochrome secreted by wood-rotting fungi. The structure and functional role of the enzyme are reviewed, and a mechanism through which the enzyme produces superoxide, ferrous iron and hydrogen peroxide is proposed. The reactions of hydroxyl radicals formed by Fenton chemistry are discussed in the context of lignocellulose biodegradation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biodegradation, Environmental
  • Carbohydrate Dehydrogenases / metabolism*
  • Hydroxyl Radical / metabolism*
  • Phanerochaete / enzymology


  • Hydroxyl Radical
  • Carbohydrate Dehydrogenases
  • cellobiose-quinone oxidoreductase