Syndecan-2 Expression Enhances Adhesion and Proliferation of Stably Transfected Swiss 3T3 Cells

Cell Biol Int. 2003;27(12):1005-10. doi: 10.1016/j.cellbi.2003.09.004.

Abstract

Syndecans (heparan sulfate proteoglycans) participate in cell-cell and cell-matrix adhesion and are co- and low-affinity receptors for growth factors and enzymes, respectively. We examined the influence of stable syndecan-2 expression in Swiss 3T3 cells on cell-adhesion and proliferation. Higher syndecan-2 expression changed cell morphology and increased spreading and adhesion in these cells and proliferation induced by FCS and FGF-2. This emphasizes the role of syndecan-2 in the integration of signals from soluble and insoluble factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blotting, Western
  • Cell Adhesion
  • Cell Division
  • DNA, Complementary / metabolism
  • Densitometry
  • Fibroblast Growth Factor 2 / metabolism
  • Membrane Glycoproteins / biosynthesis*
  • Membrane Glycoproteins / physiology*
  • Mice
  • Proteoglycans / biosynthesis*
  • Proteoglycans / physiology*
  • Swiss 3T3 Cells
  • Syndecan-2
  • Time Factors
  • Transfection

Substances

  • DNA, Complementary
  • Membrane Glycoproteins
  • Proteoglycans
  • Sdc2 protein, mouse
  • Fibroblast Growth Factor 2
  • Syndecan-2