Association of intercellular adhesion molecule-1 gene with type 1 diabetes

Lancet. 2003 Nov 22;362(9397):1723-4. doi: 10.1016/S0140-6736(03)14847-7.


Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Mellitus, Type 1 / genetics*
  • Humans
  • Intercellular Adhesion Molecule-1 / genetics*
  • Pedigree
  • Polymorphism, Single Nucleotide*


  • Intercellular Adhesion Molecule-1