Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4477-80. doi: 10.1016/j.bmcl.2003.08.079.

Abstract

A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for the treatment of depression.

MeSH terms

  • Antidepressive Agents / chemical synthesis
  • Antidepressive Agents / therapeutic use
  • Binding Sites
  • Clinical Trials as Topic
  • Depressive Disorder / drug therapy
  • Duloxetine Hydrochloride
  • Humans
  • Kinetics
  • Norepinephrine / antagonists & inhibitors*
  • Serotonin Uptake Inhibitors / chemical synthesis
  • Serotonin Uptake Inhibitors / chemistry*
  • Serotonin Uptake Inhibitors / pharmacology
  • Structure-Activity Relationship
  • Thiophenes / chemistry*
  • Thiophenes / therapeutic use

Substances

  • Antidepressive Agents
  • Serotonin Uptake Inhibitors
  • Thiophenes
  • Duloxetine Hydrochloride
  • Norepinephrine