The role of the prefrontal cortex in object-place learning: a test of the attribute specificity model

Behav Brain Res. 2003 Nov 30;146(1-2):159-65. doi: 10.1016/j.bbr.2003.09.024.


In order to test an attribute specificity model of prefrontal cortex function, rats with lesions in the prelimbic-infralimbic (PL-IL) or anterior cingulate and precentral (AC-PC) subregions of the medial prefrontal cortex and controls were trained on an object-place paired associate task. Rats with AC-PC lesions acquired the task as readily as controls. In contrast, the PL-IL lesioned rats did not learn the task. Whenever higher order processing is required to solve a task, the data support an attribute-specificity model of prefrontal cortex function in that the PL-IL cortices support both object and place attribute information in a variety of tasks including object-place paired associate learning.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Association Learning / physiology*
  • Behavior, Animal
  • Limbic System / anatomy & histology
  • Limbic System / physiology*
  • Models, Biological*
  • Prefrontal Cortex / anatomy & histology
  • Prefrontal Cortex / physiology*
  • Rats
  • Reaction Time
  • Space Perception / physiology*