Sam68, the KH domain-containing superSTAR

Biochim Biophys Acta. 2003 Dec 5;1653(2):73-86. doi: 10.1016/j.bbcan.2003.09.001.


Sam68 is one of the most studied members of the STAR family of RNA-binding proteins since its identification over a decade ago. Since its ascension into prominence, enormous progress has been made to unmask the link between the RNA-binding properties of Sam68 and the regulation of cellular processes including signal transduction, cell cycle regulation and tumorigenesis and RNA biogenesis in general. In this review we provide a detailed description of the functional domains of Sam68 and the possible biological roles that justify its superSTAR status.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Cell Cycle
  • Cell Transformation, Neoplastic
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Humans
  • Molecular Sequence Data
  • Phosphoproteins / genetics
  • Phosphoproteins / physiology*
  • Protein Structure, Tertiary
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / physiology*
  • Sequence Homology, Amino Acid
  • Signal Transduction


  • Adaptor Proteins, Signal Transducing
  • DNA-Binding Proteins
  • GAP-associated protein p62
  • KHDRBS1 protein, human
  • Phosphoproteins
  • RNA-Binding Proteins