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, 555 (2), 419-23

Amadori-glycated Phosphatidylethanolamine Induces Angiogenic Differentiations in Cultured Human Umbilical Vein Endothelial Cells

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Amadori-glycated Phosphatidylethanolamine Induces Angiogenic Differentiations in Cultured Human Umbilical Vein Endothelial Cells

Jeong-Ho Oak et al. FEBS Lett.

Abstract

Glycation has been implicated in the endothelial dysfunction that contributes to both diabetes- and aging-associated vascular complications. The aim of the present study was to determine whether Amadori-glycated phosphatidylethanolamine (Amadori-PE), a lipid-linked glycation compound that is formed at an increased rate in hyperglycemic states, affected proliferation, migration and tube formation of cultured human umbilical vein endothelial cells (HUVEC). Amadori-PE at a low concentration of less than 5 microM significantly enhanced these three factors involved in angiogenesis. Furthermore, stimulation of HUVEC with Amadori-PE resulted in secretion of matrix metalloproteinase 2 (MMP-2), a pivotal enzyme in the initial step of angiogenesis. Our results demonstrated for the first time that Amadori-PE may be an important compound that promotes vascular disease as a result of its angiogenic activity on endothelial cells. We also demonstrated that MMP-2 is a primary mediator of Amadori-PE-driven angiogenesis.

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