Effects of atorvastatin and pravastatin on glucose tolerance in diabetic rats mildly induced by streptozotocin

Biol Pharm Bull. 2003 Dec;26(12):1681-4. doi: 10.1248/bpb.26.1681.

Abstract

Effects of atorvastatin and pravastatin on glucose tolerance in mildly induced diabetic rats by streptozotocin at 24 mg/kg, i.v. were studied. Non-diabetic and diabetic rats were given orally 0.5% carboxymethylcellulose (control), 8 mg/kg atorvastatin or 8 mg/kg pravastatin once a day for 6 weeks. An oral glucose tolerance test (OGTT) was carried out 1, 2, 3, and 6 weeks after the administration. The blood glucose and plasma insulin levels measured before OGTT in the diabetic rats were not different from those in the non-diabetic rats. However, the hyperglycemic response to OGTT in the diabetic rats significantly exceeded that in the non-diabetic rats. The plasma insulin increased by OGTT in the diabetic rats appeared to be lower than that in the non-diabetic rats. Statin treatments for 1 week did not modify the OGTT-induced hyperglycemia appreciably, although there were some significant differences. More than 2 weeks after administration, the blood glucose levels at several time points after a glucose intake in the atorvastatin-treated diabetic rats were significantly higher than the respective levels in the control diabetic rats. Neither atorvastatin nor pravastatin modified the OGTT-induced insulin secretion. Statins, especially atorvastatin, may influence the glucose tolerance in mildly induced diabetic rats without alterations of insulin secretion.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Animals
  • Atorvastatin
  • Blood Glucose / analysis
  • Blood Glucose / drug effects
  • Diabetes Mellitus, Experimental / drug therapy*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Interactions
  • Glucose / administration & dosage
  • Glucose Tolerance Test / adverse effects*
  • Glucose Tolerance Test / methods
  • Heptanoic Acids / administration & dosage
  • Heptanoic Acids / pharmacokinetics*
  • Heptanoic Acids / therapeutic use
  • Injections, Intravenous
  • Insulin / biosynthesis
  • Insulin / blood
  • Insulin / metabolism
  • Insulin Secretion
  • Male
  • Pravastatin / administration & dosage
  • Pravastatin / pharmacokinetics*
  • Pravastatin / therapeutic use
  • Pyrroles / administration & dosage
  • Pyrroles / pharmacokinetics*
  • Pyrroles / therapeutic use
  • Rats
  • Rats, Sprague-Dawley
  • Streptozocin / administration & dosage
  • Streptozocin / adverse effects*
  • Time Factors

Substances

  • Blood Glucose
  • Heptanoic Acids
  • Insulin
  • Pyrroles
  • Streptozocin
  • Atorvastatin
  • Glucose
  • Pravastatin