Pharmacology of KB-R7943: A Na+-Ca2+ Exchange Inhibitor

Cardiovasc Drug Rev. Winter 2003;21(4):255-76. doi: 10.1111/j.1527-3466.2003.tb00121.x.

Abstract

The Na+-Ca2+ exchange (NCX) system plays a pivotal role in regulating intracellular Ca2+ concentration in cardiomyocytes, neuronal cells, kidney and a variety of other cells. It performs a particularly important function in regulating cardiac contractility and electrical activity. One of the leading NCX inhibitors is KB-R9743 (KBR) that appears to exhibit selectivity for Ca2+-influx-mode NCX activity (reverse mode of NCX). In this article we reviewed pharmacology of KBR and provide a brief summary of studies with other NCX inhibitors, such as SEA0400 (SEA) and SN-6 (SN). Potential clinical usefulness of KBR and other NCX inhibitors is still controversial but the reviewed findings may be helpful in designing more selective and clinically useful NCX inhibitors for the treatment of cardiac, neuronal and kidney diseases.

Publication types

  • Review

MeSH terms

  • Action Potentials / drug effects
  • Acute Kidney Injury / drug therapy*
  • Animals
  • Anti-Arrhythmia Agents* / adverse effects
  • Anti-Arrhythmia Agents* / pharmacology
  • Anti-Arrhythmia Agents* / therapeutic use
  • Humans
  • Reperfusion Injury / prevention & control*
  • Sodium-Calcium Exchanger / antagonists & inhibitors*
  • Sodium-Calcium Exchanger / physiology
  • Thiourea* / adverse effects
  • Thiourea* / analogs & derivatives*
  • Thiourea* / pharmacology
  • Thiourea* / therapeutic use

Substances

  • 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate
  • Anti-Arrhythmia Agents
  • Sodium-Calcium Exchanger
  • Thiourea