Significance of plasma endothelin-1 levels in patients with systemic sclerosis

J Rheumatol. 1992 Oct;19(10):1566-71.


Endothelin-1 (ET-1) is a novel potent vasoconstrictor peptide discovered in the supernatant fraction of cultured endothelial cells. We measured plasma levels of ET-1 using a sensitive sandwich enzyme immunoassay. Plasma concentrations of ET-1 in 31 patients with systemic sclerosis (SSc) (1.90 +/- 0.47 pg/ml) were higher than those (1.31 +/- 0.10 pg/ml) in 25 age and sex matched healthy subjects. Patients with SSc with diffuse scleroderma had higher levels of ET-1 compared with those with limited scleroderma. Plasma ET-1 levels correlated inversely with carbon monoxide diffusing capacity (DLco). Measurement of plasma ET-1 levels may be useful as a predictor of prognosis of SSc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Autoantibodies / analysis
  • Carbon Monoxide / metabolism
  • Endothelins / blood*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Raynaud Disease / blood
  • Raynaud Disease / immunology
  • Scleroderma, Systemic / blood*
  • Scleroderma, Systemic / pathology


  • Autoantibodies
  • Endothelins
  • Carbon Monoxide