Biomimetic studies on polyenes

Org Biomol Chem. 2003 Nov 7;1(21):3670-84. doi: 10.1039/b306933h.


The crispatenes and SNF4435 C&D are complex polypropionate derived natural products. The core structures of these compounds along with a complex unnatural structure can be easily prepared from a common polyene precursor simply by variation of the reaction conditions. The reaction pathways provide insight into the biosynthesis of these complex natural products.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Models, Molecular
  • Molecular Mimicry*
  • Polyenes / chemistry*
  • X-Ray Diffraction


  • Polyenes