Preoperative treatment with oestradiol in women scheduled for vaginal operation for genital prolapse. A randomised, double-blind trial

Maturitas. 1992 Dec;15(3):241-9. doi: 10.1016/0378-5122(92)90208-l.


Objective: To disclose a clinical and histopathological effect of local low-dose oestradiol treatment on the vagina.

Design: A randomised, double-blind trial.

Setting: Two gynaecological departments at University Hospitals.

Subjects: Forty-eight postmenopausal women scheduled for surgery because of genital prolapse.

Intervention: 25 micrograms oestradiol or placebo, administered as vaginal pessaries daily, 3 weeks prior to surgery.

Main outcome measures: Cytological, histological and clinical changes of the vaginal mucosa.

Results: The thickness of the vaginal wall increased as did the oestrogenic index. No clinical effect was seen apart from decreased incidence of recurrent cystitis postoperatively.

Conclusions: Preoperative oestrogen treatment has been shown to reduce the incidence of recurrent cystitis and may be needed for stimulation of vaginal mucosa; the short-term clinical effect is not convincing, however.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Aged
  • Aged, 80 and over
  • Atrophy
  • Biopsy, Needle
  • Cystitis / etiology
  • Cystitis / prevention & control
  • Double-Blind Method
  • Estradiol / administration & dosage*
  • Female
  • Humans
  • Middle Aged
  • Pessaries
  • Postoperative Complications / prevention & control
  • Preoperative Care*
  • Uterine Prolapse / surgery*
  • Vagina / pathology
  • Vaginal Smears


  • Estradiol