This article investigates the mind-body connection in chronic pain. A discussion of pain physiology is designed to identify the role of the neurological system in chronic pain perception. The gate control theory and the neurotransmitter theory of pain are explored. A description of mind-body and pain management methods, and an illustrative case study are provided. The information presented concerning mind-body connection in chronic pain perception will enable practicing nurses to be more fully aware of the chronic pain phenomenon, and lead to better chronic pain assessment, management, and evaluation.