The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population

Tissue Antigens. 2004 Jan;63(1):72-4. doi: 10.1111/j.1399-0039.2004.00153.x.


In addition to the known human leukocyte antigen (HLA)-associated risk, polymorphisms of insulin gene region show association with type 1 diabetes. We analyzed possible interactions between the HLA class II genotypes and -2221 MspI (insulin) INS gene polymorphism in Finnish population, using a series of 1331 diabetic children and 2222 healthy newborns. C/C genotype was increased among diabetic children compared to the controls (83.2 vs 70.1%). This genotype was slightly more common in diabetic children with low or moderate HLA-associated risk than in those with high risk, but INS gene effect was clear in all major HLA-risk genotypes and, thus, can be used as an additional risk prediction marker, irrespective of HLA genotypes.

MeSH terms

  • Child
  • Diabetes Mellitus, Type 1 / genetics*
  • Finland
  • Genetic Predisposition to Disease*
  • Genotype
  • HLA Antigens / genetics*
  • HLA Antigens / immunology
  • Humans
  • Insulin / genetics*
  • Polymorphism, Genetic / genetics*


  • HLA Antigens
  • Insulin