Rad53: a controller ensuring the fine-tuning of histone levels

Cell. 2003 Nov 26;115(5):508-10. doi: 10.1016/s0092-8674(03)00931-0.

Abstract

Checkpoint proteins are activated in response to genotoxic insults or replication stress to maintain genome integrity. Their function is believed to depend largely on the detection of the DNA damage or defects occurring during replication fork progression.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics*
  • Checkpoint Kinase 2
  • DNA Damage / genetics*
  • DNA Replication / genetics*
  • Genes, cdc / physiology
  • Genomic Instability / genetics
  • Histones / metabolism*
  • Humans
  • Protein-Serine-Threonine Kinases / genetics*
  • Saccharomyces cerevisiae Proteins*

Substances

  • Cell Cycle Proteins
  • Histones
  • Saccharomyces cerevisiae Proteins
  • Checkpoint Kinase 2
  • Protein-Serine-Threonine Kinases
  • RAD53 protein, S cerevisiae