Roc, a Ras/GTPase domain in complex proteins

Biochim Biophys Acta. 2003 Dec 7;1643(1-3):5-10. doi: 10.1016/j.bbamcr.2003.08.008.


We identified a novel group of the Ras/GTPase superfamily, termed Roc, that is present as domain in complex proteins together with other domains, including leucine-rich repeats (LRRs), ankyrin repeats, WD40 repeats, kinase domains, RasGEF and RhoGAP domains. Roc is always succeeded by a novel 300-400-amino-acid-long domain, termed COR. Proteins with Roc/COR are present in prokaryotes, Dictyostelium, plants and metazoa.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Dictyostelium / chemistry
  • Fungal Proteins / chemistry
  • Fungal Proteins / classification
  • Humans
  • MAP Kinase Kinase Kinases / chemistry
  • Macromolecular Substances
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • ras Proteins / chemistry*
  • ras Proteins / classification*


  • Fungal Proteins
  • Macromolecular Substances
  • MAP Kinase Kinase Kinases
  • ras Proteins