Abstract
We identified a novel group of the Ras/GTPase superfamily, termed Roc, that is present as domain in complex proteins together with other domains, including leucine-rich repeats (LRRs), ankyrin repeats, WD40 repeats, kinase domains, RasGEF and RhoGAP domains. Roc is always succeeded by a novel 300-400-amino-acid-long domain, termed COR. Proteins with Roc/COR are present in prokaryotes, Dictyostelium, plants and metazoa.
MeSH terms
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Amino Acid Sequence
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Animals
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Dictyostelium / chemistry
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Fungal Proteins / chemistry
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Fungal Proteins / classification
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Humans
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MAP Kinase Kinase Kinases / chemistry
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Macromolecular Substances
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Molecular Sequence Data
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Phylogeny
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Sequence Alignment
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Sequence Homology, Amino Acid
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ras Proteins / chemistry*
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ras Proteins / classification*
Substances
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Fungal Proteins
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Macromolecular Substances
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MAP Kinase Kinase Kinases
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ras Proteins