Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family

Biochim Biophys Acta. 2003 Nov 30;1630(2-3):130-7. doi: 10.1016/j.bbaexp.2003.09.004.


We have cloned a novel member of the mouse protein phosphatase 2C family, PP2Ceta. Sequence analysis suggests that PP2Ceta, PP2Czeta and NERPP-2C constitute a unique subgroup of the PP2C family. PP2Ceta had extremely low activity against alpha-casein compared with PP2Calpha and was localized mainly in cell nuclei, suggesting that PP2Ceta dephosphorylates a unique nuclear protein(s) in the cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • Expressed Sequence Tags
  • Molecular Sequence Data
  • Phosphoprotein Phosphatases / genetics*
  • Protein Phosphatase 2C


  • Phosphoprotein Phosphatases
  • Protein Phosphatase 2C

Associated data

  • GENBANK/AK040194
  • GENBANK/AK056894
  • GENBANK/AY332616
  • GENBANK/BC011803