Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population

J Hypertens. 2003 Dec;21(12):2251-7. doi: 10.1097/00004872-200312000-00012.


Objective: To investigate whether baseline systolic blood pressure variability was a risk factor for stroke, cardiovascular mortality or cardiac events during the Syst-Eur trial.

Design: The Syst-Eur study was a randomized, double-blind, placebo-controlled trial, powered to detect differences in stroke rate between participants on active antihypertensive treatment and placebo. Systolic blood pressure variability measurements were made on 744 participants at the start of the trial. Systolic blood pressure variability was calculated over three time frames: 24 h, daytime and night-time. The placebo and active treatment subgroups were analysed separately using an intention-to-treat principle, adjusting for confounding factors using a multiple Cox regression model.

Participants: An elderly hypertensive European population.

Main outcome measures: Stroke, cardiac events (fatal and non-fatal heart failure, fatal and non-fatal myocardial infarction and sudden death) and cardiovascular mortality (death attributed to stroke, heart failure, myocardial infarction, sudden death, pulmonary embolus, peripheral vascular disease and aortic dissection).

Results: The risk of stroke increased by 80% (95% confidence interval: 17-176%) for every 5 mmHg increase in night-time systolic blood pressure variability in the placebo group. Risk of cardiovascular mortality and cardiac events was not significantly altered. Daytime variability readings did not predict outcome. Antihypertensive treatment did not affect systolic blood pressure variability over the median 4.4-year follow-up.

Conclusion: In the placebo group, but not the active treatment group, increased night-time systolic blood pressure variability on admission to the Syst-Eur trial was an independent risk factor for stroke during the trial.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure / drug effects
  • Blood Pressure / physiology*
  • Blood Pressure Monitoring, Ambulatory
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / physiopathology
  • Circadian Rhythm / drug effects
  • Circadian Rhythm / physiology
  • Double-Blind Method
  • Endpoint Determination
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension / drug therapy
  • Hypertension / epidemiology*
  • Hypertension / physiopathology*
  • Male
  • Middle Aged
  • Observer Variation
  • Predictive Value of Tests
  • Risk Factors
  • Statistics as Topic
  • Stroke / drug therapy
  • Stroke / epidemiology*
  • Stroke / physiopathology*
  • Survival Analysis
  • Systole / drug effects
  • Systole / physiology
  • Treatment Outcome


  • Antihypertensive Agents