TRP channels as cellular sensors

Nature. 2003 Dec 4;426(6966):517-24. doi: 10.1038/nature02196.


TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium Channels / chemistry
  • Calcium Channels / genetics
  • Calcium Channels / metabolism*
  • Cells / metabolism*
  • Humans
  • Ion Channel Gating
  • Models, Biological*
  • Signal Transduction*
  • TRPC Cation Channels


  • Calcium Channels
  • TRPC Cation Channels
  • Calcium