Methods to improve efficacy in suicide gene therapy approaches: targeting prodrug-activating enzymes carboxypeptidase G2 and nitroreductase to different subcellular compartments

Methods Mol Med. 2004;90:279-301. doi: 10.1385/1-59259-429-8:279.
No abstract available

MeSH terms

  • Antineoplastic Agents / pharmacokinetics*
  • Antineoplastic Agents / toxicity
  • Aziridines / administration & dosage
  • Aziridines / pharmacokinetics
  • Aziridines / toxicity
  • Bystander Effect
  • Cell Survival / drug effects
  • Female
  • Genes, Transgenic, Suicide / genetics*
  • Genetic Therapy / methods*
  • Glutamates / administration & dosage
  • Glutamates / pharmacokinetics
  • Humans
  • Nitrogen Mustard Compounds / administration & dosage
  • Nitrogen Mustard Compounds / pharmacokinetics
  • Nitroreductases / genetics*
  • Nitroreductases / metabolism
  • Ovarian Neoplasms
  • Prodrugs / pharmacokinetics*
  • Prodrugs / toxicity
  • Subcellular Fractions / enzymology
  • Transfection / methods
  • Tumor Cells, Cultured
  • gamma-Glutamyl Hydrolase / genetics*
  • gamma-Glutamyl Hydrolase / metabolism*

Substances

  • Antineoplastic Agents
  • Aziridines
  • Glutamates
  • Nitrogen Mustard Compounds
  • Prodrugs
  • 4-((2-chloroethyl)(2-mesyloxyethyl)amino)benzoylglutamic acid
  • tretazicar
  • Nitroreductases
  • gamma-Glutamyl Hydrolase