A role for JNK-paxillin signaling in cell migration

Cell Cycle. 2004 Jan;3(1):4-6.

Abstract

Recently, we and others demonstrated that JNK is essential for cell migration in a number of cell types. We also showed that JNK phosphorylates serine 178 on paxillin, a focal adhesion adaptor, both in vitro and in vivo. Moreover, phosphorylation of Ser 178 on paxillin is essential for cell migration and involved in modulating cell adhesions. A model is proposed to depict the role of JNK-paxillin signaling in cell migration.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology
  • Cell Movement / physiology*
  • Cytoskeletal Proteins / metabolism*
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • Humans
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases / metabolism*
  • Paxillin
  • Phosphoproteins / metabolism*
  • Phosphorylation
  • Protein-Tyrosine Kinases / metabolism
  • Signal Transduction / physiology*

Substances

  • Cytoskeletal Proteins
  • PXN protein, human
  • Paxillin
  • Phosphoproteins
  • Protein-Tyrosine Kinases
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • PTK2 protein, human
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases